Harshad Rai
Thacore
Place of Birth: India
Citizen of: United States of America
EDUCATION
Lucknow Christian College, Lucknow, - India, B.Sc., 1958
Lucknow University, Lucknow - India, M.Sc., 1960
Duke University, Durham, North -
Carolina, Ph.D., 965
ACADEMIC POSITIONS
Emeritus
Professor (Retired) Department of
Microbiology and Immunology
State University of NY at Buffalo- 2011 Associate Professor Department of Microbiology and Immunology 1979 – 2011 State
University of NY at Buffalo
Assistant Professor Department of Microbiology and
Immunology
1974-1979
State University of NY at Buffalo
Assistant Research Professor Department of Microbiology
1971-1974
University of Pittsburgh
Instructor Department of
Microbiology 1969 - 1971
University
of Pittsburgh
Research Associate Department of Microbiology 1967 - 1969
University
of Pittsburgh
Postdoctoral Fellow Department of Microbiology 1965 - 1967
Ohio
State University
TRAINING
IN RECOMBINANT DNA TECHNOLOGY:
Recipient of Individual Faculty
Development Grant (IFDG): Guest
Researcher at National Institutes of Health with Dr. Manfred Schubert,
Laboratory of Molecular Genetics from July 1 to August 11, 1985. Hands on experience in techniques involving
recombinant DNA technology such as preparation of plasmid DNA, transformation
of bacteria by plasmid DNA, characterization of plasmids, cloning of DNA
fragments into vectors, vaccinia virus, hybridization and electrophoretic
procedures.
SABBATICAL
LEAVE:
May 1, 1993- November 30, 1993
During my sabbatical leave I worked
in the laboratory of Dr. Paul J. Davis, Chairman, Department of Medicine,
Albany Medical College, Albany, New York. I was involved in several research
projects, some were continuation of our collaboration which began almost a
decade ago. During my stay I acquired
certain skills in techniques dealing with molecular biology, such as, cDNA
technology including Polymerase Chain Reaction (PCR) related to the research
projects. I also interacted in a
positive manner with several faculty members, graduate and medical students in
the Department of Medicine as well as researchers from the Wadsworth Center For
Laboratories and Research, Albany, New York.
PROFESSIONAL
MEMBERSHIPS:
American Society for Microbiology
Sigma Xi
American Association for the
Advancement of Science
American Society for Virology
International Society for
Interferon Research
The Buffalo Collegium of Immunology
DEPARTMENTAL
SERVICE:
GRADUATE
PROGRAM AND MEDICAL SCHOOL TEACHING
TEACHING
RESPONSIBILITIES:
Graduate Program, Medical and Dental Schools and Undergraduate Program
Course
Director:
Present:
MIC 301-Medical Microbiology and Immunology
for Health Related Professions
Past:
MIC
516 Laboratory Methods in
Microbiology and Immunology (1980-1984)
MIC
619-20 Microbiology Seminar (1984)
MIC
600 Medical Microbiology and
Immunology (Co-Course Leader)
(1988-1991)
Participation
as a Lecturer:
Present:
MIC 301 Medical Microbiology for Health
Related Professions
MIC 302 Microworld
MIC 501 Graduate Microbiology
MIC
502 Medical and Oral
Microbiology
IMC
504 Fundamentals II:
Principles of Disease and Therapy
IMC 604 Lung and Respiration
MIC
700 Thesis Guidance
SBM-IDM-511 Scientific Basis of Medicine
2007:
Helping in developing topics in virology of a prospective “International
Health” course at UB medical school for fall of 2008.
Past:
MIC 600 Medical Microbiology and Immunology
MIC 611 Principles
and Techniques of Cell and Organ Culture
MIC 600H Honors Course in Medical Microbiology
MIC 622 Immunochemistry
MIC 511 Medical Microbiology for Graduate Students
MIC 612 Fundamentals of Virology
MIC 613 Defense Mechanisms in Virus Infection
MIC 649 Animal
Virology Research
MIC 616 Special Seminars in Clinical Microbiology
and Immunology
Participation as a Lecturer:
Department of Cell and Tumor
Biology, Roswell Park Cancer Institute
Past:
MIR
530 Mammalian
Interferons
MIR
614 Molecular Basis of
Animal Virology
RESEARCH
SUPERVISION OF GRADUATE STUDENTS
Department of Microbiology, School
of Medicine and Biomedical Sciences
Major Advisor:
T.R.
Winship M.A. 1977
Ph.D. 1979
G.
Williams M.A. 1979
Ph.D. 1982
P.K.
Kibler* M.A. 1985
Ph.D. 1988
H-Y.
Lin M.A. 1991
Ph.D. 1991
*Recipient of the Erwin Neter Award
for presentation of research at the Western New York Branch of the American Society
for Microbiology, 1987.
Committee Member for Graduate
Student Research:
M.A. only (1975-present):
Gary Klaich
Mohammed
Al-Ahdal
Ivette
Lorenzana
Andrew
Gurien
Robert
Tyrrell
Committee Member for Graduate
Student Research: Continued:
M.A. and/or Ph.D. (1975-present):
Marie
Gallagher
Paula
Krasnoff
Tanveer
(Haider) Abidi
Zhigang
Paul Zhou
Gang
Yang
Weerachai
Ladakom
Jay
Samuel
Howard
Wallace II
Dwayne Boucaud
Scientific Reviewer for Ph.D.
Thesis:
Linda
Moore
Jonathan
Reichner
Hari
Cohly
Frank
Swartzwelder
Cynthia
Vernon
Jian-Jun
Chen
Chaoyuan
Chen
Yousef
Abu Kwaik
Inside Reader for Ph.D. Thesis:
Maryanne
Simurda
Nancy
Lewis
Elaine
M. Haase
COMMITTEE
ACTIVITIES:
Department of Microbiology:
Preliminary
Examination Committee (member, 1977-present; chairman, 1977-1980, 1991-1992)
Laboratory
Manual (chairman, 1979-present)
Audiovisual
Committee (member, 1976-present)
Generation
of Funds through Teaching Committee (member, 1982-present)
Admissions
Committee (member, 1982-1997)
MIC
600 Final Examination Committee (member, 1978-1984; chairman 1982-1984, 1995)
Associate
Director of Graduate Studies (1994-1996)
School of Medicine and Biomedical
Sciences:
Curriculum
Committee of the Faculty Council (member, 1980-1982)
New
Course Committee of the Faculty Council (member, 1980-1982)
Faculty
Council (member, 1985-1988; 1995-present)
Student
Affair Committee (member, 1984-1985)
Committee
for Appointment and Promotion to Research Ranks (1993-1995)
Vertical
Resource Group Advisor (1993-present)
Appeals Committee (1998-present)
UNDERGRADUATE
EDUCATION:
Director
of Undergraduate Studies: 2006-present
TEACHING
RESPONSIBILITIES:
Department
of Microbiology:
Course
Director:
Present:
MIC
301 Fundamentals of Microbiology (1998-Present)
Course-Co-coordinator:
Past:
MIC
301 Fundamentals of Microbiology
(1985-1998)
MIC 302- Microworld (Lecturer)
RESEARCH PROJECT FOR UNDERGRADUATE
STUENTS:
MIC
499 Independent Study (1997; 2006)
UNDERGRADUATE EDUCATION:
Department Representative for
Science Committee (1992-1993)
RESEARCH
INTERESTS:
Primary interest is in the field of
Virology. Most of the work during my
tenure in this department has been involved with studies dealing with
virus-cell interactions. One of the major areas of interest deals with the
study of the interferon system, which includes the induction of interferons by
various interferon inducers as well as the development of antiviral state
against both RNA and DNA viruses.
Currently (2007) involved in
studies dealing with entry and pathogenesis, including cytokine production by
avian influenza virus (H5N2) in human cells of the upper and lower respiratory
tract. A comparative study is underway with human influenza virus (H3N2).
Past research activities:
These involved elucidating the
mechanisms involved in the interference mediated by viral mutants (point) and
deletion mutants (defective interfering particles). In addition, the role of signal
transduction in the interferon system was extensively studied using specific
inhibitors. These studies elucidated the various pathways in the signal
transduction process in the interferon system. These studies were performed by
my graduate students and resulted in publications and presentations at national
and international virology meetings.
Past research collaborations:
Collaborations with Dr. Hudecki,
Department of Biological Sciences, SUNYAB, dealt with the role of interferons
in immunomodulation in muscular dystrophy in chickens; emphasis on the
expression of calmodulin and the Duchene dystrophy genes in dystrophic chicken.
Current research:
Current research involves studying
the response(s) of mammalian cells in culture to foreign nucleic acid,
primarily single-stranded RNA molecules derived from viroids. These molecules
have unique structure, hairpin and base pairing. It is hypothesized that
mammalian cells will respond to these non-coding RNA molecules by activating
the signal transduction pathway(s) resulting in the production of cytokines.
Preliminary experiments are being
conducted using potato spindle tuber viroid (PSTVd) cDNA obtained from Dr.
Owens, US Department of Agriculture, Maryland. These cDNA clones have been
cloned in mammalian expression vectors to generate new constructs which will be
used in transfection experiments to test the hypothesis.
Current research collaborations:
I have been collaborating with Dr.
Davis, Chairman, Department of Medicine, Albany Medical College, Albany, NY,
for the past 13 years. We have attempted to characterize cellular signal
transduction mechanisms involved in the production of interferons and other
cytokines as well as in the development of antiviral state and
antiproliferative activity of interferons.
I am also collaborating with
departmental faculty members (Dr. Cunningham and Dr.Albini) in studying various
aspects of the pathogenesis of Murine AIDS induced by MuLV in mice. This
involves examination of the cells involved in the immune system including
production of cytokines.
Invitations
to present research at International Congress for Virology Meeting
l. Paper
entitled "Inhibition of vesicular stomatitis virus-defective interfering
particle synthesis by Shope fibroma virus" was presented at the Fourth
International Congress for Virology, The Hague, The Netherlands, 1978.
2. International
Workshop on Interferons.
Honorarium. Chairman M. Krim,
Sloan Kettering Cancer Institute, New York, New York, 1979.
3. Participation
in a round-table discussion of my research entitled "Genetic analysis of a
heterotypically interfering defective interfering particle of vesicular
stomatitis virus containing the entire L gene" at the Seventh International
Congress of Virology, Edmonton, Alberta, Canada, 1987.
Invitation to present at an
International Muscular Dystrophy Association Meeting
1.
MDA Workshop: Myoblast
Implantation. New York City, June 10-11,
1989.
RESEARCH
COLLABORATIONS:
My training in recombinant DNA
technology at the National Institutes of Health has allowed me to perform
specialized techniques. This has allowed
me to collaborate with the following persons in an attempt to answer questions
in certain diseases at the level of gene expression. This has expanded my research base to areas
other than virology which still remains my primary research interest.
1.a Dr.
Paul J. Davis and Dr. Faith B. Davis, Department of Medicine, Albany Medical
College, Albany, NY. Interactions of
interferons and calmodulin. The
expression of sarcoplasmic reticulum Ca2+-ATPase and calmodulin genes in dystrophic
muscle. Role of protein kinase C and
calmodulin in the interferon system.
2.a Dr.
Michael Hudecki, Department of Biological Sciences, SUNYAB. Role of interferons in immunomodulation in
muscular dystrophy in chickens. The
expression of calmodulin and Duchene dystrophy genes in dystrophic chickens.
3.a Dr.
Joseph H. Kite, Jr., Department of Microbiology, SUNYAB. Lymphokines and autoimmunity. Expression of interferon and interleukin-2
genes in autoimmune thyroiditis.
4. Dr.
Manfred Schubert, Laboratory of Molecular Genetics, National Institutes of
Health, Bethesda, Maryland. Viral
interference: Genetic analysis of VSV
DI-particles using cDNA clones of VSV genes.
5.a Dr.
Roger Cunningham, Department of Microbiology, SUNYAB. Studies dealing with the genetic control of
the responsiveness of spleen cells from normal and MAIDS mice to interleukin-2
and the expression of interleukin-2 receptors.
6a. Dr.
Thomas D. Flanagan, Department of Microbiology, SUNYAB. Studies involved in the cell-mediated immune
responses to Sendai virus glycoproteins.
7.a Dr.
Boris Albini, Department of Microbiology, SUNYAB and Dr. Stefan A. Cohen,
Department of Medicine, Buffalo General Hospital. In vitro studies dealing with production of
interferons and interleukin-2 receptors in tumor cells.
8.a Dr. S. Ohki, Department of Physiology
& Biophysics, SUNYAB. Entry of viruses into
cells. Role of viral glycoproteins
in fusion and entry of viruses into cells.
9.a Dr. Hung-Yun Lin, Ordway
Research Institute, Inc, Albany, New York
A
Collaborations resulted in publications.
COMMUNITY
SERVICE: SCIENTIFIC PRESENTATION:
1. "Hepatitis
and Herpes Viruses in Dental Medicine" to the Dental Hygienist Association, Buffalo, NY, 1982.
2. "Interferons: Impact in Microbiology and Medicine" to
the Niagara Frontier Science Supervisors Association, Amherst, NY, 1987.
3. "Interferons: A Unique Lymphokine with Antiviral
Activity" to Endocrinology group at Veteran's Administration Medical
Center, Buffalo, NY 1987.
4. "Lymphokines"
presented to Fellows, Clinical and Anatomic Pathology and members of
professional staff, at the Veteran's Administration Medical Center, Buffalo,
NY, 1987.
5. Seminar
on herpes viruses to the medical staff of the Deaconess Center, Buffalo General
Hospital, December 13, 1991.
COMMUNITY
SERVICE:
Participation in the Minority High
School Research Apprentice Program in the School of Medicine and Biomedical
Sciences:
Student: Karen Tsu Kada, 1987
Member of the Duke University
Alumni Interviewing Team: Interview
local area high school students for admission to Duke University.
Editorial
Activities:
Ad hoc reviewer for the following
journals:
Proceedings
of the Experimental Biology and Medicine
Immunological
Investigations
Infection
and Immunity
Preparative
Biochemistry
Reviewer for Grants:
March of Dimes Foundation, NY
Veterans Administration
Research
Fundings:
Grant
Pending: 2005 (NIH)
Co-Investigator: Biophysical Study of Viral Glycoproteins in
Viral Fusion
1. Individual Development
Award-July 1, 1998-August 31,1999
Development of a serologic test to type venom of C.mildei
2. Department
of Veterans Affairs: Mechanisms of
thyroid hormone on Calcium ATPase and
Interferon
Co-Investigator
(P.I. Paul Davis)
Support
period : 3/95 to 3/00
Total
amount: $518,000
Past Research Funding: (1984-87)
Principal Investigator:
1. New
chicken interferon: Cloning and
antiproliferative activity in human cells.
Interdisciplinary
Grant Award: Total award $l0,000
2. In
vitro transcription and translation of respiratory syncytial virus.
Interdisciplinary
Grant Award: Total award $3,000
3. Calmodulin
gene expression in genetically dystrophic muscle. Co-Principal Investigator. Muscular
Dystrophy Association.
Support
period: 1/1/88 to 12/31/88
Total
amount: $20,000
4. Contract
with Sandoz Pharmaceuticals Corporation, East Hanover, NJ, for testing
antimicrobial drug.
Support
period: 10/22/91 to 12/31/93
Total
amount: $10,000
Co-Principal Investigator:
1. Effect
of drug therapy on hereditary muscular dystrophy.
Support
period: 4/1/89 to 3/31/92
Muscular
Dystrophy Association: Total
amount: $134,290
2. Genetic
expression of calmodulin protein in dystrophic muscle.
Interdisciplinary
Grant Award: Total award $l6,2l3
3. Studies
on dystrophic chickens
Muscular
Dystrophy Association: Total award
$47,000
Grant Applications Submitted but
not Funded: 1986
1a. New
chicken interferon: Cloning and anti-proliferative
activity in human cells.
Principal
Investigator: NSF
2. Reduction
of tumor growth following immune dysfunction.
Co-Principal
Investigator: NIH and NSF
3. Immune
dysfunction in autoimmune thyroiditis
Co-Principal
Investigator: NIH
4b. Gene
expression in muscular dystrophy.
Co-Principal
Investigator: MDA
5. Cell-mediated
immune responses to viral glycoproteins.
Co-Principal
Investigator: NIH
A Revisions are in progress for
resubmission.
B Missed funding by 0.25
points. Revised grants have been
resubmitted.
PUBLICATIONS:
l. Thacore,
H. and Willett, H.P. Formation of
spheroplasts of Mycobacterium tuberculosis by lysozyme treatment. Proc. Soc. Exp. Biol. Med. ll4: 43-47, 1963.
2. Thacore,
H. and Willett, H.P. The formation of
spheroplasts of Mycobacterium tuberculosis in tissue culture cells. Amer. Rev. Resp. Dis. 93: 786-796, 1966.
3. Willett,
H.P. and Thacore, H. The induction by
lysozyme of an L-type growth in Mycobacterium tuberculosis. Can. J. Microbiol. l2: ll-l6, 1966.
4. Willett,
H.P. and Thacore, H. Formation of
spheroplasts of Mycobacterium tuberculosis by lysozyme in combination with
certain enzymes of rabbit peritoneal monocytes.
Can. J. Microbiol. l3: 48l-488,
1967.
5. Thacore,
H. and Wolff, D.A. Isolation and
characterization of lysosome-rich fractions from cultured cells. Exp. Cell Res. 49: 266-276, 1968.
6. Thacore,
H. and Wolff, D.A. Activation of
isolation lysosomes by poliovirus-infected cell extracts. Nature 2l8: l063-l064, 1968.
7. Thacore,
H. and Youngner, J.S. Cells persistently
infected with Newcastle disease virus.
I. Properties of mutants isolated
from persistently infected L cells. J.
Virol. 4: 244-25l, 1969.
8. Thacore,
H. and Youngner, J.S. Cells persistently
infected with Newcastle disease virus.
II. Ribonucleic acid and protein
synthesis in cells infected with mutants isolated from persistently infected L
cells. J. Virol. 6: 42-48, 1970.
9. Hallum,
J.V., Thacore, H.R. and Youngner, J.S.
Factors affecting the sensitivity of different viruses to interferon. J. Virol.
6: l56-l62, 1970.
l0. Thacore,
H.R. and Youngner, J.S. Cells
persistently infected with Newcastle disease virus. III.
Thermal stability of hemagglutinin and neuraminidase of a mutant
isolated from persistently infected L cells. J. Virol.
7: 53-58, 197l.
ll. Hallum,
J.V., Thacore, H.R. and Youngner, J.S.
Effect of exogenous interferon on L cells persistently infected with
Newcastle disease virus. Infect.
Immun. 5: l45-l46, 1972.
l2. Thacore,
H.R. and Youngner, J.S. Viral ribonucleic
acid synthesis by Newcastle disease virus mutants isolated from persistently
infected L cells: Effects of
interferon. J. Virol. 9: 503-509, 1972.
l3. Youngner,
J.S., Thacore, H.R. and Kelly, M.E.
Sensitivity of ribonucleic acid and deoxyribonucleic acid viruses to
different species of interferon in cell cultures. J. Virol.
l0: l7l-l78, 1972.
l4. Thacore,
H.R. and Youngner, J.S. Different
sensitivity of ribonucleic and deoxyribonucleic acid viruses to resistance
induced in rabbit cells (RK-l3) by polyriboinosinic acid polyribocytidilic
acid. Infect. Immun. 7: 685-690, 1973.
l5. Thacore,
H.R. and Youngner, J.S. Rescue of
vesicular stomatitis virus from interferon-induced resistance by superinfection
with vaccinia virus. I. Rescue in cell cultures from different
species. Virology 56: 505-5ll, 1973.
l6. Thacore,
H.R. and Youngner, J.S. Rescue of
vesicular stomatitis virus from interferon-induced resistance by superinfection
with vaccinia virus. II. Effect of UV-inactivated vaccinia and
metabolic inhibitors. Virology 56: 5l2-522, 1973.
l7. Thacore,
H.R. and Youngner, J.S. Persistence of
vesicular stomatitis virus in interferon-treated cell cultures. Virology 63: 345-35l, 1975.
l8. Thacore,
H.R. and Youngner, J.S. Abortive infection
of a rabbit cornea cell line by vesicular stomatitis virus: Conversion to
productive infection by superinfection with vaccinia virus. J. Virol.
l6: 322-329, 1975.
19. LaMontagne,
J.R., Schiller, J.G., Thacore, H.R., Feingold, D.S. and Youngner, J.S. Infective and non-infective hemagglutinating
particles of Newcastle disease virus: Biologic and chemical
characterization. J. Virol. l6: l19l-l199, 1975.
20. Thacore,
H.R. Rescue of vesicular stomatitis
virus from homologous and heterologous interferon-induced resistance in human
cell cultures by poxviruses. Infect.
Immun. l4: 3ll-3l4, 1976.
2l. Thacore,
H.R. Effect of interferon on
transcription and translation of vesicular stomatitis virus in human and simian
cell cultures. J. Gen. Virol. 4l: 42l-426, 1978.
22. Winship,
T.R. and Thacore, H.R. Inhibition of
vesicular stomatitis virus-defective interfering particle synthesis by shope
fibroma virus. Virology 93: 5l5-526,
1979.
23. Winship,
T.R. and Thacore, H.R. A sensitive
method for quantitation of VSV-defective interfering particles: Focus forming
assay. J. Gen. Virol. 48: 237-240, 1980.
24. Thacore,
H.R. and Winship, T.R. Host restriction
property of vesicular stomatitis virus mutant isolated from carrier
cultures. J. Gen. Virol. 54: 449-452,
198l.
25. Thacore,
H.R., Mount, D.T. and Chadha, K.C.
Interferon system of human cornea cells: Interferon production,
characterization and development of antiviral state. J. Interferon Res. 2: 70-77, 1982.
26. Williams,
G.J. and Thacore, H.R. Generation and
characterization of a non-defective interfering particle of vesicular
stomatitis virus: Homotypic and heterotypic interference. J. Gen. Virol. 64: l4l5-l420, 1983.
27. Thacore,
H.R., Kibler, P.K., Gregorio, C.C. Pollina, C.M. and Hudecki, M.S. Characterization of lymphocyte interferons
with different species specificities from normal and genetically dystrophic
chickens. J. Interferon Res. 5: 279-288,
1985.
28. Davis,
P.J., Thacore, H.R., Chadha, K.C., Lawrence, W.D. and Kite, J.H., Jr. Interferon-calmodulin interaction: Effect on calmodulin bioactivity. Biochem. Biophys. Res. Comm. l33: ll3-l19, 1985.
29. Mitchell,
Y., Thacore, H.R. and Chadha, K.C.
Modulation of the interferon antiviral activity by adriamycin in human
cells in culture. Antiviral Res. 6:
ll3-l22, 1986.
30. Hudecki,
M.S., Kibler, P.K., Pollina, C.M., Thacore, H.R., Davis, P.J. and Davis,
F.B. Abnormal expression of the
calmodulin gene in muscle from the dystrophic chicken. Biochem. Biophys. Res. Comm. l37: 507-5l2,
1986.
3l. Thacore,
H.R., Kibler, P.K., Hudecki, M.S., Pollina, C.M., Galindo, Jr., J., Blas, S.D.,
Schoenl, M., Davis, F.B. and Davis, P.J.
Early abnormal development of calmodulin expression and Ca2+-ATPase
activity in avian dystrophic muscle. Biochem.
Biophys. Res. Comm. l5l: l434-l440, 1988.
32. Galindo,
J., Hudecki, M.S., Davis, F.B., Davis, P.J., Thacore, H.R., Pollina, C.M.,
Blas, S.D. and Schoenl, M. Abnormal
response to calmodulin in vitro of dystrophic chicken muscle sarcoplasmic
reticulum Ca2+-ATPase. Biochemistry 27:
7519-7524, 1988.
33. Zhou,
P., Quackenbush, L.J., Thacore, H.R., Akinbami, C. and Zaleski, M.B. Factors affecting proliferation of non-immune
T cells in vitro. Trans. Proc. 21:
171-173, 1989.
34. Lin,
H.-Y., Davis, P.J., Davis, F.B., Chadha, K.C. and Thacore, H.R. Effect of calmodulin antagonists on the
interferon system: Induction and action
of interferons. J. Interferon Res. 10:
40-48, 1990.
35. Lin,
H.-Y. and Thacore, H.R. Role of
calmodulin/protein kinase C in interferon production by poly(rI)poly(rC) in
primed human cell cultures. J.
Interferon Res. 10: 375-378, 1990.
36. Thacore,
H.R., Lin, H-Y., Davis, P.J. and Schoenl, M.
Effect of protein kinase C inhibitors on interferon-b production by viral and non-viral
inducers. J. gen Virology 71: 2833-2839,
1990.
37. Lin,
H-Y. and Thacore, H.R.
Negative-regulatory role of calmodulin in the expression of
interferon-beta gene. J. Biol.
Regulators and Homeostatic Agents 5:
86-90, 1991.
38. Lin,
H-Y., Davis, P.J. and Thacore, H.R.
Production of human interferon-beta by Sendai virus and
poly(rI)poly(rC): Inhibition by
neomycin. J. Interferon Res. 11:
365-369, 1991.
39.
Chadha, K.C., Stadler, I.,
Albini, B., Nakeeb, S.M. and Thacore, H.R.
Effect of alcohol on spleen cells and their functions in C57 BL/6
mice. Alcohol 8: 481-485, 1991.
40. Thacore,
H.R., Cunningham, R.K., Zhou, P., Nakeeb, S., Terzian, R. and Zaleski,
M.B. Acquired immunodeficiency in murine
lymphoproliferative disease:
Considerations on pathogenesis.
Immunobiol. 190 195-211, 1994.
41. Cunningham,
R.K., Thacore, H.R., Zhou, P., Nakeeb, S. and Zaleski, M.B. Blood transfusion as a means for transmission
of retrovirus-induced lymphoproliferative disease in mice. Intl. Arch. Allergy and Immunol. 103: 16-22,
1994.
42. Lin,
H-Y., Thacore, H.R., Davis, P.J. and Davis, F.B. Thyroid hormone potentiates the antiviral
action of interferon-gamma in cultured human cells. J. Clinical Endocr. Metab. 79: 62-65,
1994.
43. Cunningham,
R.K., Thacore, H.R., Zhou, P., Terzian, R., Nakeeb, S. and Zaleski, M.B. Murine AIDS:
A model for the human disease or a distinct entity? Immunol. Res. 13: 21-28, 1994.
44. Cunningham,
R.K., Thacore, H.R., Zhou, P., Nakeeb, S. and Zaleski, M.B. Retrovirus-induced lymphoproliferative
disease in mice undergoing graft-versus-host reaction. Immunol. Invest. 24:
881-890,1995.
45. Zaleski,
M.B., Thacore, H.R., Zhou, P., Dubiski, S., Nakeeb, S. and Cunningham,
R.C. Retrovirus-induced
lymphoproliferative disease in mice: Role of humoral immunity in perinatally
exposed mice. Immunobiol. 194: 390-402, 1995.
46. Thacore,
H.R., Cunningham, R.K., Nakeeb, S. and Zaleski, M.B. Quantitative aspects of transfusion-transmitted retrovirus-induced
lymphoproliferative disease in mice.
Journal of Clinical and
Laboratory Immunology 46: 97-109, 1995.
47. Lin, H-Y., Davis, F.B., Thacore, H.R.,
and Davis, P.J. Potentiation by thyroxine of interferon-gamma induced HLA-DR
expression is protein kinase A-and C-dependent. J. Interferon and Cytokine Res.
16: 17-24, 1996.
48. Lin,
H-Y., Thacore, H.R., Davis, F.B. and Davis, P.J. Thyroid hormone analogues potentiate the
antiviral action of interferon-gamma by more than one mechanism. Journal of Cellular Physiology. 167: 269-276,
1996.
49. Hung-Yun
Lin, Harshad R. Thacore, Faith B. Davis, and Paul J. Davis. Potentiation by thyroxine of
interferon-gamma-induced antiviral state requires PKA and PKC activities. Amer.
Phys. Soc. C1256-C1261, 1996.
50. Ohki,
S., Thacore, H. and Flanagan, T.D. Effect on viral glycoprotein mobility and a
possible role of internal “viroskeleton” proteins in Sendai virus fusion.
Journal of Membrane Biology. 199: 73-83, 2004.
CHAPTERS
IN TEXTBOOKS
l. Thacore,
H.R. Measles Virus, Mumps Virus, Rubella
Virus. Medical Microbiology, F. Milgrom
and T.D. Flanagan, eds., Churchill Livingstone, Inc., New York, 1982.
2. Thacore,
H.R. Coronavirus, Reovirus, Rotavirus
Infections. Medical Microbiology, F.
Milgrom and T.D. Flanagan, eds., Churchill Livingstone, Inc., New York, 1982.
3. Thacore,
H.R. Hepatitis Viruses. Medical Microbiology, F. Milgrom and T.D.
Flanagan, eds., Churchill Livingstone, Inc., New York, 1982.
4. Flanagan,
T.D. and Thacore, H.R. Interferon and
Chemotherapy of Viral Infections. Medical
Microbiology, F. Milgrom and T.D. Flanagan, eds., Churchill Livingstone, Inc.,
New York, 1982.
5. Thacore, H.R. Viruses. Microbiology and Immunology for
Health Related Professions. Pearson Custom Publishing, Boston, MA. 2000.
6. Thacore, H.R. Viral Hepatitis.
Microbiology and Immunology for Health Related Professions. Pearson Custom
Publishing, Boston, MA. 2000.
7. Thacore, H.R. Orthomyxoviridae.
Microbiology and Immunology for Health Related Professions. Pearson Custom
Publishing, Boston, MA. 2000.
8. Thacore, H.R. Human Immunodeficiency
Virus (HIV) and AIDS. Microbiology and Immunology for Health Related
Professions. Pearson Custom Publishing, Boston, MA. 2000.
EDITOR
OF TEXT BOOK:
TEXT
BOOK USED IN MIC 301 COURSE at University at Buffalo- 2005
Microbiology
and Immunology for Health Related Professions.
Pearson
Custom Publishing, 2009.
ABSTRACTS
Presentations
at National and International Meetings
l. Hallum,
J.V., Youngner, J.S. and Thacore, H.
Inhibition of interferon induction and virus replication in L cells
pretreated with interferon. Bacteriol.
Proc. l50, 1969.
2. Thacore,
H.R. and Youngner, J.S. Properties of
mutants of Newcastle disease virus isolated from persistently infected L
cells. Bacteriol. Proc. 193, 1969.
3. Hallum,
J.V., Thacore, H. and Youngner, J.S.
Factors affecting viral sensitivity to interferon in chick embryo cell
cultures. Bacteriol. Proc. l6l, 1970.
4. Thacore,
H.R. and Youngner, J.S. Macromolecular
biosynthesis during productive and abortive replication of Newcastle disease
virus mutants in L cells. Bacteriol.
Proc. 190, 1970.
5. Hallum,
J.V., Thacore, H.R. and Youngner, J.S.
Effect of interferon on L cells persistently infected with Newcastle
disease virus. Bacteriol. Proc. l87, 197l.
6. Thacore,
H.R. and Youngner, J.S. Vaccinia
infection of L-cells reverses interferon-induced resistance against vesicular
stomatitis virus. Abstracts of the Ann.
Meeting of the Amer. Soc. for Microbiol. 206, 1973.
7. Thacore,
H.R. and Youngner, J.S. Persistence of
vesicular stomatitis virus in interferon-treated cell cultures. Abstracts of the Ann. Meeting of the Amer.
Soc. for Microbiol. 1974.
8. Preble,
O.T., Thacore, H.R. and Youngner, J.S.
Activation of virus replication in L cells persistently infected with
Newcastle disease virus. Abstracts of
the Ann. Meeting of the Amer. Soc. for Microbiol. 1974.
9. Thacore,
H.R. and Youngner, J.S. Abortive
infection of a rabbit cornea cell line by vesicular stomatitis virus:
Conversion to productive infection by superinfection with vaccinia virus. Abstracts of the Ann. Meeting of the Amer.
Soc. for Microbiol. 246, 1975.
l0. Thacore,
H.R. Variation in the ability of Shope
fibroma virus to rescue vesicular stomatitis virus from interferon-induced
resistance in human cell lines.
Abstracts of the Ann. Meeting of the Amer. Soc. for Microbiol. 238, 1976.
ll. Winship,
T.R. and Thacore, H.R. Inhibition of
vesicular stomatitis virus defective interfering particle synthesis in monkey
kidney cells by Shope fibroma virus (ShFV).
Abstracts of the Ann. Meeting of the Amer. Soc. for Microbiol. 1977.
l2. Thacore,
H.R. Effect of homologous and
heterologous interferon on vesicular stomatitis virus transcription and
translation in human and simian cells.
Abstracts of the Ann. Meeting of the Amer. Soc. for Microbiol. 1978.
l3. Winship,
T.R. and Thacore, H.R. Inhibition of
vesicular stomatitis virus-defective interfering particle synthesis by Shope fibroma
virus. Abstract in Fourth International
Congress for Virology, The Hague, The Netherlands, 1978.
l4. Thacore,
H.R. Properties of vesicular stomatitis
virus mutants: Host restriction.
Abstracts of the Ann. Meeting of the Amer. Soc. for Microbiol., 1980.
l5. Williams,
G.J. and Thacore, H.R. Generation of
small-plaque mutants during undiluted passages of vesicular stomatitis virus in
a simian cell line. Abstracts of the
Ann. Meeting of the Amer. Soc. for Microbiol., 1982.
l6. Williams,
G.J. and Thacore, H.R. Generation and
characterization of a non-defective interfering particle of vesicular
stomatitis virus: Homotypic and heterotypic interference. First Ann. Meeting of the Amer. Soc. for
Virology, 1982.
l7. Thacore,
H.R. Heterotypic interference by a
non-transcribing defective interfering particle of vesicular stomatitis
virus. Ann. Meeting of the Amer. Soc.
for Virology, 1984.
l8. Yarvin,
M., Thacore, H.R. and Chadha, K.C.
Influence of adriamycin or production and antiviral action of interferon. Ann. Meeting of the Amer. Soc. for Virology,
1984.
19. Davis,
P.J., Thacore, H.R., Kite, J.H., Jr., Chadha, K.C., Lawrence, W.D. and Schoenl,
M. Calmodulin content of interferon
preparation. Ann. Meeting of the Assoc.
of American Physicians (Clinical Research), 1985.
20. Thacore,
H.R., Kibler, P.K., Gregario, C.C., Pollina, C.M. and Hudecki, M.S. Characterization of lymphocyte interferons
with different species specificities from normal and genetically dystrophic
chickens. Ann. Meeting of the Amer. Soc.
for Virol., 1985.
2l. Kibler,
P.K. and Thacore, H.R. A heterotypic
interfering DI particle from the 5' end
of a VSVIND mutant: Characterization of
its biological and genetic proper ties. Ann. Meeting of the Amer. Soc. for Virology,
1985.
22. Davis,
F.B., Davis, P.S., Hudecki, M.S., Thacore, H.R. and Blas, S.D. Thyroid hormone action in vitro on chicken
skeletal muscle sarcoplasmic reticulum Ca2+-ATPase: Calmodulin antagonism of thyroid hormone in
dystrophic muscle. The Endocrine Society,
1986.
23. Hudecki,
M.S., Thacore, H.R., Kibler, P.K., Davis, P.J., Davis, F.B., Blas, S.D.,
Galindo, J., Gregorio, C.C. and Pollina, C.M.
Development of abnormal calmodulin gene expression and related
activities in genetically dystrophic chicken muscle. Society for Neuroscience, Washington, D.C.,
1986.
24. Kibler,
P.K. and Thacore, H.R. Genetic analysis
of a heterotypically interfering defective interfering particle of vesicular
stomatitis virus containing the entire L gene.
Ann. Meeting of the Amer. Soc. for Virol., 1987.
25. Kibler,
P.K. and Thacore, H.R. Genetic analysis
of a heterotypically interfering defective interfering particle of vesicular
stomatitis virus containing the entire L gene.
Abstract in the VIIth International Congress of Virology, Edmonton,
Alberta, Canada, 1987.
26. Quackenbush,
L.J., Dowjat, W.K., Kibler, P., Thacore, H., Zhou, P., Smith, A. and Zaleski,
M.B. Interleukin-2 driven proliferation
of normal murine spleen cells: A genetic
analysis. Ann. Meeting of FASEB, 1987.
27. Thacore,
H.R., Galindo, J., Davis, P.J., Davis, F.B., Farrel, M., Kite, Jr., J.H.,
Schoenl, M. and Pollina, C. Thyroid
hormone increases calmodulin and Ca2+-ATPase mRNAs in avian skeletal and
cardiac muscle. The Endocrine Society,
1988.
28. Lin,
H.-Y., Davis, P.J., Davis, F.B., Chadha, K.C. and Thacore, H.R. Effect of interferon antagonists on the
interferon system: Induction and action
of interferons. Ann. Mtg. ASV, 1989.
29. Thacore,
H.R., Lin, H.-Y., Davis, F.B. and Chadha, K.C.
Effect of calmodulin antagonists on interferon system: Induction and action of interferons. Annual Meeting of the International Society
for Interferon Research, Florence, Italy, 1989.
30.
Lin, H-Y., Davis, P.J.,
Chadha, K.C. and Thacore, H.R.
Interferon mediated cellular antiviral state: Different signal transduction pathways for
IFN-a/b and IFN-g. Annual meeting of the
International Society for Interferon Research, Nice, France, 1991.
31. Zaleski,
M.B., Thacore, H.R., Cunningham, R.K., Stadler, I., Zhou, P., Nakeeb, S. and
Chadha, K. IL-2 driven proliferation of
spleen cells from murine AIDS mice.
FASEB, 1992.
32. Thacore,
H.R, Lin, H-Y., Davis, F.B. and Davis, P.J.
Thyroid hormone potentiates the antiviral action in vitro of human
interferon-gamma: Role of
phosphoproteins. American Society for
Virology, Ithaca, NY, 1992.
33. Lin,
H-Y., Thacore, H.R., Davis, P.J., Davis, F.B., Chadha, K.C. and Hogan,
J.E. Discrete signal transduction
pathways are involved in induction by interferon a/b and g of the cellular
antiviral state. Clinical Research,
Texas, 1992.
34. Lin,
H-Y., Thacore, H.R., Davis, P.J., Davis, F.B. and Hogan, J.E. Thyroid hormone potentiates the antiviral
action of interferon-gamma in human fibroblasts. Annual meeting of Endocrine Society,
Baltimore, Maryland, 1992.
35. Thacore,
H.R., Lin, H-Y., Davis, F.B., Davis, P.J. and Hogan, J.E. Phosphorylation of p19 (Stathmin) is an early
step in interferon action. Annual
meeting of the International Society for Interferon Research, Toronto, Canada,
1992.
36. Thacore,
H.R., Cunningham, R.K., Zhou, P., Terzian, R., Nakeeb, S. and Zaleski, M.B. Acquired immunodeficiency in
murine lymphoproliferative disease. IXth
International Congress of Virology, Glasgow, Scotland, 1993.
37. Thacore,
H.R., Davis, F.B., Hogan, J.E. and Davis, P.J.
Phosphorylation of cytosolic p19 in response to homologous
interferon-gamma in primary cultures of human fibroblasts. IXth International Congress of Virology, Glasgow,
Scotland, 1993.
38. Thacore,
H.R., Cunningham, R.K., Nakeeb, S., Zhou, P. and Zaleski, M.B. Transmission of retrovirus-induced murine
lymphoproliferative disease by blood or plasma transfusion. XIIth International Convocation on
Immunology, Buffalo, New York, 1994.
39. Lin,
H-Y., Thacore, H.R., Davis, F.B. and Davis, P.J. Potentiation by thyroid hormone of the
antiviral action of interferon-gamma in human cells is protein
kinase-dependent. The Endocrine Soc.
Annual Meeting, Anaheim, California, 1994.
40. Lin,
H-Y., Davis, F.B., Martino, L.J., Hogg, M.G., Thacore, H.R. and Davis,
P.J. Thyroid hormone potentiates
rHuIFN-g-induced HLA-DR expression in HeLa cells by a protein kinase-dependent
mechanism. Thyroid 4:suppl. S-79 (post
#115), 1994.
41. Lin,
H-Y, Thacore, H.R., Davis, F.B. and Davis, P.J.
The potentiation by thyroid hormone of rHuIFN-gamma-induced antiviral
activity is protein kinase and phsopholipase C-dependent. Thyroid 4:suppl. S-79 (post #118), 1994.
42. Lin,
H-Y, Davis, F.B., Martino, L.J., Hogg, M.G., Thacore, H.R. and Davis, P.J. Thyroid hormone potentiates rHuIFN-g-induced
HLA-DR expression in HeLa cells by a protein kinase-dependent mechanism. Great Lakes Endocrinology Annual Meeting,
Buffalo, New York, 1994.
43. Davis,
F.B., Thacore, H.R., Lin, H-Y., Davis, P.J., Hogen, J.E. and Gombas, D.Z. Signal transduction pathways involved in the
antiviral action of interferons dependent on concentrations of
interferons. The American Soc. for Cell
Biology Annual Meeting, San Francisco, California, 1994.
44. Lin,
H-Y., Thacore, H.R., Davis, F.B. and Davis, P.J. Thyroid hormone analogues potentiate the
antiviral action of interferon-g by more than one mechanism. American Federation for Clinical Research,
San Diego, California, 1995.
45. Davis,
F.B., Thacore, H.R., Lin, H-Y. and Davis, P.J.
Potentiation by thyroxine of rHuIFN-gamms-induced HLA-DR expression is
protein kinase C-dependent. First Annual
AMC/RPI Joint Research Symposium, Albany, New York, 1995.
46. Lin,
H-Y, Thacore, H.R., Davis, F.B. and Davis, P.J.
Thyroid hormone analogues potentiate the antiviral action of
interferon-gamma by more than one mechanism.
First Annual AMC/RPI Joint Research Symposium, Albany, New York, 1995.
47. Lin,
H-Y., Thacore, H.R., Davis, F.B. and Davis, P.J. Potentiation by thyroxine of interferon-gamma-induced
HLA-DR expression is modulated by inhibitors of protein kinases A and C. Annual Meeting of the Endocrine Soc.,
Washington, DC, 1995.
48. Davis,
F.B., Thacore, H.R., Lin, H-Y. and Davis, P.J.
Protein kinase C activation is essential for potentiation by thyroxine
of interferon-gamma-induced HLA expression. International Thyroid Congress,
Toronto, Ontario, Canada, 1995.
49. Lin,
H-Y., Thacore, H.R., Davis, F.B. and Davis, P.J. Potentiation by thyroxine of
interferon-gamma-induced HLA-DR expression in HeLa cells depends on activated
protein kinases A and C. International
Soc. for Interferon and Cytokine Research.
Baltimore, Maryland, 1995.
50. Thacore, H.R., R.K. Cunningham, P. Zaou,
S. Dubiski, S. Nakeeb, and Zaleski, M.B. Perinatal mother-to-offspring transmission
of MAIDS. Amer. Soc. For Virology, Montana, USA.
51. Ohki, S, Thacore, H.R. Flanagan, T.D. Effect
of temperature on fusion of Sendai virus with target membranes and mobility of
viral glycoproteins. Annual Meeting of the Biophysical Society, Baltimore,
Maryland, 2004.